Two molecules. One universal blood.
Blood compatibility is governed by two surfaces: the ABO sugars and the Rh(D) protein. BioIchor is the only platform that addresses both — enzymatically erasing A/B antigens and immunologically masking Rh — to turn every donation into universal O‑negative.
Engineered Glycosidases
Directed‑evolution variants of bacterial glycosyl hydrolases cleave the terminal N‑acetylgalactosamine (A) and galactose (B) residues from red‑cell surface glycans. The result: an ABO‑null cell, indistinguishable from native O at the antigenic level.
- >99.99% antigen removal by flow cytometry
- No detectable membrane damage or hemolysis
- Single‑step, room‑temperature reaction
Anti‑Rh Masking Fab
A proprietary, computationally designed antibody fragment binds the Rh(D) protein at the exact epitope recognized by alloimmune anti‑D antibodies. The Fab cloaks the antigen without triggering clearance — converting Rh‑positive cells into immunologically silent, Rh‑negative‑equivalent units.
- Picomolar affinity, non‑agglutinating
- Sterically blocks anti‑D recognition
- Composition‑of‑matter patent (BioIchor IP)
The process
Identify
Donated whole blood enters our closed‑loop processor and is typed in seconds via surface‑marker spectroscopy.
Cleave
Engineered glycosidases selectively remove the terminal sugars that define A and B antigens — leaving the red cell membrane intact and fully functional.
Mask
Our patented Fab binds the Rh(D) protein with picomolar affinity, sterically blocking recognition by anti‑D antibodies without depleting the cell.
Verify & Deliver
Optical, flow‑cytometric and immunoassay QC confirm >99.99% conversion before the unit leaves the system as functional O‑negative blood.